The effect of tocopherol to the teratogenecity due to chlorambucil have been studied on the developing skeleton in prenatal offsprings from 27 mothers of albino rat through macroscopic and microscopic observations.
1. None of the significant abnormality has been observed on either macroscopic or microscopic features in the fetal group treated with single dose of tocopherol administration to the mother, except, the group treated with continuous 3 doses of it to the mother, of which the measures of the weight and stature of them are generally decreased than those of the normal contrast.
2. Though the degree of teratogenecity on the developing fetal skeletal frame due to the chlorambucil is mainly depend upon the amount of the drug and the time of administration during pregnancy of mother, the highest teratogenetic effect could be elicitable on the fetuses at the day 12th, while, none of significant effect could be detectable in the fetuses after the time of day 14th of pregnancy on the administration of the chlorambucil.
3. The protective effectiveness of the tocopherol from the teratogenecity on the fetal skeletogenesis due to the chlorambucil appears not to be efficient. On the contrary, the concomitant use of tocopheral with chlorambucil tends to be facilitate the teratogenetic effect of the chlorambucil, furthermore, the rate is higher against with increase of the date of pregnancy.
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